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Biopreparedness in Nebraska

COVID-19

On December 31, 2019, the WHO documented that their country office in China was notified of several cases of a pneumonia of unknown cause in Wuhan, China. Patients suffering from the illness were not responding to standard treatments. By January 7, 2020, public health officials in China had identified a novel coronavirus as the cause of the outbreak. Less than two weeks later, the Centers for Disease Control and Prevention (CDC) reported the first laboratory-confirmed case in the United States. On January 31, 2020, the WHO declared the outbreak a Public Health Emergency of International Concern (PHEIC). With over 118,000 confirmed cases across 114 countries on March 11, 2020, the WHO declared COVID-19 a pandemic.

As defined by the CDC, coronavirus disease (COVID-19) is a respiratory infectious disease caused by the SARS-CoV-2 virus. The virus causes severe acute respiratory issues and spreads from person to person through respiratory droplets and small particles released from an infected person’s mouth or nose when they cough, sneeze, speak, or breathe.

 

SARS-CoV-2 Virus

Courtesy of iEXCEL Visualization

SARS-CoV-2

The SARS-CoV-2 virus is related to a family of coronaviruses including SARS-CoV-1 that caused the 2002-2004 SARS (severe acute respiratory syndrome) epidemic and the MERS (Middle East respiratory syndrome) which initially appeared in 2012. COVID-19 causes flu-like symptoms and attacks the lungs, with severe cases requiring intubation and a ventilator to help a patient breathe. It can also be spread by asymptomatic individuals. Preventive actions like washing hands, masking, vaccinations, and social distancing continue to be important protocols for combatting the disease.

 

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Camp Ashland Entrance, 2020

Courtesy of the UNMC Department of Strategic Communications

Camp Ashland’s housing facilities were used as a quarantine location so UNMC/Nebraska Medicine medical professionals could monitor patients' coronavirus symptoms.

UNMC/Nebraska Medicine’s First Contact with COVID-19

On February 7, 2020, UNMC/Nebraska Medicine answered the national call to support 57 Americans returning from Wuhan, China, in need of quarantine and care during the initial outbreak of COVID-19. Upon arrival at Eppley Airfield in Omaha, they were safely and securely transported to the Nebraska National Guard’s Camp Ashland location for a 14-day quarantine period as mandated by the Centers for Disease Control and Prevention (CDC). Only one person developed minor respiratory symptoms and was transported to the National Quarantine Unit on the UNMC/Nebraska Medicine campus. This person was returned to Camp Ashland after two negative coronavirus tests to complete the rest of their quarantine period. By February 20th, all 57 patients were released.

The operation to return these Americans from China was a collaborative effort between UNMC/Nebraska Medicine, the U.S. Department of Health and Human Services, the CDC, Douglas County Health Department, Sarpy-Cass County Health Department, Lincoln-Lancaster Health Department, Nebraska Emergency Management Agency, Nebraska Department of Health and Human Services, Three Rivers Health Department, and the Nebraska National Guard.

 

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First Diamond Princess Patients Released, 2020

Courtesy of the UNMC Department of Strategic Communications

Jeri Serattie Goldman, left, and Joanne Kirkland, right, spoke in a press conference about their time in the National Quarantine Unit.

Quarantining Passengers of the Diamond Princess Cruise Ship

On February 13, 2020, UNMC/Nebraska Medicine received 13 Americans from the Diamond Princess cruise ship, which had been docked off the coast of Japan. Later, two additional passengers from the Diamond Princess were transferred to UNMC and united with their spouses in quarantine. Of the 15 passengers that UNMC/Nebraska Medicine received, 13 tested positive for COVID-19. All the patients were housed at the National Quarantine Unit on the UNMC/Nebraska Medicine campus. Some were housed in the Nebraska Biocontainment Unit to receive more intensive care.

All the passengers eventually recovered and were released over the course of the month of March 2020 after two consecutive negative tests for the coronavirus. The first four patients were released on March 2 and the final patient on March 18. This final departure completed the federal operation supported by UNMC/Nebraska Medicine that began with the 57 American evacuees from Wuhan, China.

 

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PPE awaiting UV treatment

Courtesy of the UNMC Department of Strategic Communications

Biocontainment Personal Protective Equipment, c. 2020

Donated by Angela Hewlett, MD, medical director of the Nebraska Biocontainment Unit, from the McGoogan Health Sciences Library Special Collections and Archives

The Powered Air Purifying Respirator level Personal Protective Equipment (PAPR PPE) featured here was worn in the NBU to treat patients with severe COVID-19 symptoms.

Global PPE Shortage

As COVID-19 spread across the world, hospitals were faced with a shortage of the personal protective equipment (PPE) needed to keep health care providers safe when treating patients. In March 2020, in response to the shortage, John-Martin Lowe, PhD, director of research and development for the NBU, led a team of scientists in developing a UV system for decontaminating PPE for re-use. This process was shared globally, providing health care systems with an avenue for lengthening the life of their PPE.

 

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COVID-19 Diagnostic Testing

Courtesy of the UNMC Department of Strategic Communications

COVID-19 Diagnostic Testing

Shortly after development of the first CDC testing kits for COVID-19, scientists in public health labs across the U.S. confirmed the tests were faulty. While the Nebraska Public Health Laboratory worked to fix the test kits on hand, M. Jana Broadhurst, MD, PhD, DTM&H, director of the Emerging Pathogens Laboratory, and her team worked with the CDC to develop better and faster diagnostic testing. They eventually created the saliva Polymerase Chain Reaction (PCR) test featured below.

CDC COVID-19 Test Kits, 2020

In a rush to provide testing to health care centers across the country, the Centers for Disease Control and Prevention (CDC) unfortunately released faulty kits , like the ones displayed here. The error was quickly discovered by the labs of UNMC and Nebraska Medicine, who worked with the CDC to remedy the issue.

ONPACE Simulator, January 2021

The Oral Nasal Pharyngeal Anatomy Clinical Education (ONPACE) training system was designed by UNMC iEXCEL, in collaboration with the Chamberlain Group, to teach the correct COVID-19 test swabbing technique. It provides a clear side view for instructor evaluation and observation. Done incorrectly, the nasal swab could deliver a false negative result or worse, damage the patient’s septum.

COVID-19 PCR Saliva Test, November 2020

In the search for effective testing methods for COVID-19, a team in the Emerging Pathogens Laboratory at UNMC developed this novel saliva Polymerase Chain Reaction (PCR) test for fast and accurate screening. Collecting a sample is easy—you just spit in a tube! Clinical trials proved the test to be very effective at detecting COVID-19 in asymptomatic individuals.

 

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Andre Kalil, MD, MPH

Courtesy of LuAnn Larson, RN, BSN, Director of Clinical Research Operations at Nebraska Medicine

National Institute of Health Clinical Trials

In February 2020, Andre Kalil, MD, MPH, led a team at Nebraska Medicine in enrolling some of the first COVID-19 patients in a National Institute of Health clinical trial to study remdesivir as a treatment for the disease. The study confirmed remdesivir as an effective treatment and was approved for emergency use in May 2020. The drug received full FDA approval in October 2020 and continues to be a form of treatment for patients with severe COVID-19 conditions.

 

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COVID-19 Vaccine

Courtesy of the UNMC Department of Strategic Communications

COVID-19 Vaccine

On December 11, 2020, the FDA gave Emergency Use Authorization (EUA) for the Pfizer-BioNTech COVID-19 vaccine, and an EUA for the Moderna vaccine following shortly after. UNMC/Nebraska Medicine used the first doses they received to vaccinate frontline health care workers, with vaccination becoming more widely available for the public in February 2021. As the virus continues to evolve, new bivalent booster vaccinations have become the best option to protect people and decrease the spread of COVID-19.

 

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Donning COVID-19 PPE

Courtesy of iEXCEL Visualizations

Doffing COVID-19 PPE

Courtesy of iEXCEL Visualizations

Donning and Doffing COVID-19 PPE

Donning and doffing PPE in a specific order helps protect health care providers caring for patients with infectious diseases and helps prevent spread of pathogens. COVID-19 PPE is designed to protect the health care worker from exposure to the respiratory droplets that spread the virus. Click on the interactives below to explore more about donning and doffing protocols.

Donning COVID-19 PPE Interactive

Doffing COVID-19 PPE Interactive

UNMC HEROES COVID-19 Modules

 

 

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John-Martin Lowe, PhD, Director, Global Center for Health Security

Transcript

John-Martin Lowe: [I]n the COVID response and my initial roles and responsibilities, again, because I had been so involved in transport, got pulled into how do we do a lot of the local coordination and integration with federal organizations for receiving patients that are going to need to be provided medical care or monitored. So, a fair amount of liaising and pulling together those organizations here in Omaha that do all of the planning and do the piece to get people safely to the airport and from the airport to wherever they're going. Also very involved in kind of rewriting protocols. So, we have lots of protocols for viral hemorrhagic diseases. We had a variety of protocols for respiratory pathogens but, knowing what we knew and knowing what we didn't know in February of 2020, we really—it was a great opportunity to refine our protocols based off of the current body of information, or lack thereof, to kind of maximize safety. So, it was prepping for transport and doing a final deep dive on our safety protocols for the initial response where it was—we were so integrated and embedded with federal agencies, it was really just helping make sure that the federal agencies had the information that they needed and a lot of coordination on behalf of the biocontainment unit with different federal agencies that thought they might have somebody that would need to come to the biocontainment unit.

 

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Peter Iwen, PhD, Director, Nebraska Public Health Laboratory

Transcript

Peter Iwen: [T]he CDC got in big trouble, you probably remember reading it in the news, because of their test. It was too complicated to begin with. Second off, they didn't know what was wrong with it. So they came to us, the special pathogens lab at the CDC's directors called us up in a meeting to ask us for our help to find out what is wrong with their test. So we did some laboratory manipulations and told them, “You know, this is what we think is wrong with your tests.” And they corrected that, resubmitted it to the FDA to get emergency use authorization approval. And lo and behold, they had a test that worked. But that was pretty touchy for the CDC because they had everybody looking at them saying, “You blew it guys.” And some of those people no longer work in that lab [laughter] unfortunately. But we were part of that process. It was because we had a relationship with the CDC in the past and we knew their directors and they looked at us, said, “Hey, can you help us?” So it was fun, but that's what we did. And lo and behold, now a lot of labs can test for it, but—it's still something that we're dealing with.

 

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Mark Rupp, MD, Chief, Division of Infectious Diseases, College of Medicine

Transcript

Darby Kurtz: [W]hat is the role of an infectious disease professional when dealing with a pandemic?

Mark Rupp: The COVID pandemic has been incredible. It really was something that stressed the division and really the whole medical system to the breaking point, and our group and the Medical Center has responded so tremendously well and so heroically. It's really inspirational to have seen how people rallied and did what they needed to do. Sort of in comparison to the Ebola patients, that was incredibly stressful for a period of about three months. This has been incredibly stressful for going on starting our fourth year. It's been impactful not only for ID, but for all groups of clinicians. There's a lot of folks who are frayed at the edges and suffering a little bit.

 

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Jane Meza, PhD, Associate Vice Chancellor, Office of Global Engagement

Transcript

Jane Meza: And then one day we got a call over at UNO from the Health Department and they said, “We're going to need you to do contact tracing.” That was something that we were—I knew something about contact tracing, but certainly was something that I had never done and weren't really prepared to stand that up right away, but we did it. We stood up contact tracing at UNO for all of our students, because the idea was that you know as a campus better when students say they went to their math class and then they went to their engineering class. Then UNMC started to do some testing here, and I think we had like one day where people could come get tested and that was a big success. Then we realized that we need to have testing at UNO, and so we set up a testing center at UNO. Those are things I'd never done before. I never thought in a million years I would be doing this. But what was really great about it is I knew all the people at UNMC that were doing this. Talked to Dr. Hinrichs and Tony Sambol and Teresa Fowler, and next thing you knew we had a testing center set up at UNO, so that's kind of what I did at UNO. Then one day, I got a call that said Ted was looking to retire. Would I be interested in doing this at UNMC? I thought, “Well, it does make sense since I know a lot about what Ted is doing, and I know what we're doing at UNO,” so I said yes. Then for a while, I was the interim executive director for health security at both UNO and UNMC, and also associate vice chancellor for global engagement at both institutions, and that was a lot.

 

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James Lawler, MD, MPH, Associate Director, International Programs and Innovation, Global Center for Health Security

Transcript

James Lawler: I think we all essentially filled in whatever holes needed to be filled in at the time. And that's true not only at—I mentioned that kind of the Global Center team has from its inception been willing and able to wear multiple hats at any given time, doing what's necessary. I think that was true, certainly, across our entire institution here, the university and hospital, that people did what needed to be done and I think our team did that as well. So, some of it was dealing locally with things within the hospital and within the university that needed to be addressed. How do we create safe infection prevention control practices for managing patients? Advocating for airborne isolation for all the patients very early on, again, based on some of the information we were getting in some of what we saw in managing early patients. Helping response across the state and region, particularly in places that were seen to be especially vulnerable or, early on, had huge issues. So, meatpacking facilities obviously being one, right, where we put together teams and we went out to these facilities to see firsthand what was happening, where were vulnerabilities, how could we create interventions that would you know, reduce spreading and keep what is critical infrastructure running. Same thing for nursing homes and long-term care facilities, that was recognized very early on as a very vulnerable segment in society and, same thing, sent teams out and we went to these places, and you know, did training, assessed their procedures and physical layouts, and, again, did things to try and reduce risk. Schools, same thing. So, wherever we thought there was a need we would jump in.

 

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David Brett-Major, MD, Scholar, Global Center for Health Security

Transcript

David Brett-Major: I pitched a critical questions and ethics mechanism to be embedded as part of the response team and Dean Khan and Chris Kratochvil and Shelly Schwedhelm they were very receptive to this, and I reached out to two really excellent UNMC faculty members. Rachel Lookadoo, who's a public health attorney, and Abbey Lowe, who's a bioethicist, and they took on that mission and have continued to do it, convening a weekly open table responding to targeted questions and there were a lot of them initially and ultimately expanding those lanes of work when it seemed like it mattered. Abby eventually formed an external ethics board and has been managing referral ethics consultations and position papers. In addition to that group, critical questions and ethics, still operating, Rachel, with Abby and others, and with help and I think some guidance from Shelly Schwedhelm they really leaned in and organized the Nebraska Crisis of Care—Standards of Care activities. That has turned out to be really useful and I think unique. I'm not aware of an actual response team structure that's ever tried to do quite that.

 

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Elizabeth Rupp

Transcript

Elizabeth Rupp: [I]t's so frustrating, if people knew—he has nothing to gain by advocating vaccines or face masks or—he has no personal gain and he's so careful about reading the studies and analyzing them and determining the validity of the findings. “Yes, that's a good study and it makes sense and you can trust those findings” or “no, they didn't do things right.” He has—no horse in the race, so to speak. It's just like, he's working hard for the betterment of everybody, but yet people think he's motivated by some sinister or personal gain. I don't know what it is. It's just—it's hard to see that happening it’s really—when he just has dedicated his life to vanquishing these kinds of things and educating people about them, but it's not appreciated and he's criticized because of it and called names and threatened. That's hard to watch. If they knew him and knew what he was doing and how he goes about his life, they would feel very differently. And I think the access to social media is just a very scary thing that anybody can say anything they want to say and people will believe them. It's just very disheartening when the facts are not held as closely as the fallacies.

 

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UNMC/Nebraska Medicine’s Continued Response to COVID-19

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James Lawler, MD, MPH, discussing COVID-19's impact on lungs

Courtesy of the UNMC Department of Strategic Communications

Since the World Health Organization declared COVID-19 a global health emergency on January 30, 2020, UNMC/Nebraska Medicine has played an active role in confronting the virus locally and globally.

As a national leader in the study of infectious diseases and a local leader in Nebraska health care, UNMC/Nebraska Medicine has been at the forefront of the response to COVID-19, providing patient care, testing, and research. The university and medical center have served as an information resource for federal, state, and local officials, news outlets, businesses, schools, and communities.

To support these endeavors, the UNMC College of Medicine developed COVID-19 Rapid Response grants in April 2020, providing resources for faculty to study various aspects of the virus including diagnostics, prevention, treatments, and clinical research. UNMC/Nebraska Medicine has also been active in vaccine trials and distribution. As Nebraskans, Americans, and the world continue to process through the pandemic, UNMC/Nebraska Medicine is a multidimensional resource for all.

Learn more about UNMC/Nebraska Medicine’s impact during the pandemic through this timeline of a few select events.

 

UNMC COVID-19 Response Timeline

 

 

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